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src family selective tyrosine kinase inhibitor pp2  (Tocris)


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    Tocris src family selective tyrosine kinase inhibitor pp2
    Src Family Selective Tyrosine Kinase Inhibitor Pp2, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 154 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/src+family+selective+tyrosine+kinase+inhibitor+pp2/10__1042_slash_cbi20110162-37-10-19?v=Tocris
    Average 93 stars, based on 154 article reviews
    src family selective tyrosine kinase inhibitor pp2 - by Bioz Stars, 2026-08
    93/100 stars

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    UM1 (06-12) and Mel270 treatment with Src inhibitors (PP1/PP2) identified eight substrates with a significant reduction in phosphorylation ( A ). The inhibition of EFS peptide phosphorylation by genetic (Src siRNA) and pharmacological means (PP1) in cell line Mel270, and PP1 treatment of cell lysates of UM (UM1) and metastasis tissue (MET3) ( B ).

    Journal: British Journal of Cancer

    Article Title: Episodic Src activation in uveal melanoma revealed by kinase activity profiling

    doi: 10.1038/sj.bjc.6605172

    Figure Lengend Snippet: UM1 (06-12) and Mel270 treatment with Src inhibitors (PP1/PP2) identified eight substrates with a significant reduction in phosphorylation ( A ). The inhibition of EFS peptide phosphorylation by genetic (Src siRNA) and pharmacological means (PP1) in cell line Mel270, and PP1 treatment of cell lysates of UM (UM1) and metastasis tissue (MET3) ( B ).

    Article Snippet: Blocking experiments were carried out with Src family-selective tyrosine kinase inhibitors, PP1, PP2 (Biomol International, LP, of Plymouth Meeting, PA, USA) and PP3 (the inactive analogue, Calbiochem), at an end concentration of 10 μ M in line with a large body of literature.

    Techniques: Phospho-proteomics, Inhibition